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When stratified by administration route, the average percentage reductions were: Intramuscular (IM): 48.3% Sublingual: 30.7% Oral: 30.3% These results suggest that IM administration leads the most pronounced homocysteine reduction, however, sublingual and oral routes also demonstrate clinically relevant effects

[25,59, 60, 61] Tolerization with hCDR1 induced both CD4 + CD25 + and CD8 + CD28 T regs in mice, which suppressed lymphocyte proliferation and autoantibody production

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